Parameters
The Parameters dock is used for passing special variables that are applied:
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when first attaching a new individual's data
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when hitting Refresh (to reload the individual's data anew)
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when executing a Luna script
Parameters (Luna) versus configurations (Lunascope): the Param tab passes instructions to Luna itself, whereas the Config tab controls Lunascope-specific display behavior.

Some parameters are needed before data can even be attached. For example, if annotations use a nonstandard YMD date format, add date-format=YMD; otherwise loading may fail. This is equivalent to the options that come before the main Luna script:
luna s.lst 1 date-format=YMD th=2.5 @param.txt -o out.db < script.txt
In this example, date-format is a special variable that controls Luna's behavior, th is a user-defined variable required by script.txt, and @param.txt includes additional parameter values that would be loaded into this dock.
Aliases and remapping
One common use of parameter files is to rename signals (alias) and annotations (remap). If these are defined at load time, the Signals and Annotations docks show the mapped labels rather than the originals.
By default, Luna includes some built-in mappings unless annot-remap=F and/or nsrr-remap=F is set. The Parameters tab can also be used to inspect the currently defined variables and signal/annotation mappings.
Loading parameter files
You can pre-load a parameter file from the command line with -p:
lunascope s.lst -p param.txt
This pre-populates the dock with that file.